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Index > Protein center > Mx1(Gene name) > Mouse
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  • Mx1 (Gene name),
  • Interferon-induced GTP-binding protein Mx1 (Protein name ),  MX1_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Gene name:
    Mx1;
    Protein name:
    Interferon-induced GTP-binding protein Mx1;
    Alternative:
    Myxoma resistance protein 1;Influenza resistance protein;Myxovirus resistance protein 1;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts with TRPC1, TRPC3, TRPC4, TRPC5, TRPC6 and TRPC7.
    Function:
    May regulate the calcium channel activity of TRPCs. Confers selective resistance to influenza virus.
    Subcellular Location:
    Cytoplasm Nucleus Found in the nucleus of 3T3 cells, when overexpressed (PubMed:3000619). Orthologous proteins have been seen in the cytosplasm in most other species studied.
    Protein Attributes:
    Sequence length:
    631
    Sequence:
    50:
    MDSVNNLCRH | YEEKVRPCID | LIDTLRALGV | EQDLALPAIA | VIGDQSSGKS | 
    100:
    SVLEALSGVA | LPRGSGIVTR | CPLVLKLRKL | KEGEEWRGKV | SYDDIEVELS | 
    150:
    DPSEVEEAIN | KGQNFIAGVG | LGISDKLISL | DVSSPNVPDL | TLIDLPGITR | 
    200:
    VAVGNQPADI | GRQIKRLIKT | YIQKQETINL | VVVPSNVDIA | TTEALSMAQE | 
    250:
    VDPEGDRTIG | VLTKPDLVDR | GAEGKVLDVM | RNLVYPLKKG | YMIVKCRGQQ | 
    300:
    DIQEQLSLTE | AFQKEQVFFK | DHSYFSILLE | DGKATVPCLA | ERLTEELTSH | 
    350:
    ICKSLPLLED | QINSSHQSAS | EELQKYGADI | PEDDRTRMSF | LVNKISAFNR | 
    400:
    NIMNLIQAQE | TVSEGDSRLF | TKLRNEFLAW | DDHIEEYFKK | DSPEVQSKMK | 
    450:
    EFENQYRGRE | LPGFVDYKAF | ESIIKKRVKA | LEESAVNMLR | RVTKMVQTAF | 
    500:
    VKILSNDFGD | FLNLCCTAKS | KIKEIRLNQE | KEAENLIRLH | FQMEQIVYCQ | 
    550:
    DQVYKETLKT | IREKEAEKEK | TKALINPATF | QNNSQFPQKG | LTTTEMTQHL | 
    600:
    KAYYQECRRN | IGRQIPLIIQ | YFILKTFGEE | IEKMMLQLLQ | DTSKCSWFLE | 
    631:
    EQSDTREKKK | FLKRRLLRLD | EARQKLAKFS | D
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    UniGene:
    SMR:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Interferon-induced GTP-binding protein Mx1
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    E2928m
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    ELISA Kit for Mouse Interferon-induced GTP-binding protein Mx1
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    E2928b
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    Packing:
    96T
    ELISA Kit for Mouse Interferon-induced GTP-binding protein Mx1
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    E2928d
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    96T
    ELISA Kit for Mouse Interferon-induced GTP-binding protein Mx1
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    E2928r
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    ELISA Kit for Mouse Interferon-induced GTP-binding protein Mx1
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    ELISA Kit for Mouse Interferon-induced GTP-binding protein Mx1
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    E2928p
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    Packing:
    96T
    CLIA Kit for Mouse Interferon-induced GTP-binding protein Mx1
    Cat.:
    U2928p
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    Packing:
    96T
    CLIA Kit for Mouse Interferon-induced GTP-binding protein Mx1
    Cat.:
    U2928r
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Mouse Interferon-induced GTP-binding protein Mx1
    Cat.:
    U2928m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Interferon-induced GTP-binding protein Mx1
    Cat.:
    U2928b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Interferon-induced GTP-binding protein Mx1
    Cat.:
    U2928h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Interferon-induced GTP-binding protein Mx1
    Cat.:
    U2928d
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Mouse Interferon-induced GTP-binding protein Mx1
    Polyclonal Antibody for Mouse Interferon-induced GTP-binding protein Mx1
    Cat.:
    P2928Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Interferon-induced GTP-binding protein Mx1
    Polyclonal Antibody for Mouse Interferon-induced GTP-binding protein Mx1
    Cat.:
    P2928Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Interferon-induced GTP-binding protein Mx1
    Polyclonal Antibody for Mouse Interferon-induced GTP-binding protein Mx1
    Cat.:
    P2928Rb-r
    Price:
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse Interferon-induced GTP-binding protein Mx1
    Monoclonal Antibody for Mouse Interferon-induced GTP-binding protein Mx1
    Monoclonal Antibody for Mouse Interferon-induced GTP-binding protein Mx1
    Monoclonal Antibody for Mouse Interferon-induced GTP-binding protein Mx1
    Monoclonal Antibody for Mouse Interferon-induced GTP-binding protein Mx1
    Monoclonal Antibody for Mouse Interferon-induced GTP-binding protein Mx1
    Protein for Mouse Interferon-induced GTP-binding protein Mx1
    Protein for Mouse Interferon-induced GTP-binding protein Mx1
    Protein for Mouse Interferon-induced GTP-binding protein Mx1
    Protein for Mouse Interferon-induced GTP-binding protein Mx1
    Protein for Mouse Interferon-induced GTP-binding protein Mx1
    Protein for Mouse Interferon-induced GTP-binding protein Mx1

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    Linearity
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    References
    1. 1.
      "Mx protein: constitutive expression in 3T3 cells transformed with cloned Mx cDNA confers selective resistance to influenza virus."
      Staeheli P. , Haller O. , Boll W. , Lindenmann J. , Weissmann C.
      Cell44:147-158(1986) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      "Organization of the murine Mx gene and characterization of its interferon- and virus-inducible promoter."
      Hug H. , Costas M. , Staeheli P. , Aebi M. , Weissmann C.
      Mol. Cell. Biol.8:3065-3079(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: Czech II.
      tissue: Mammary gland.
    4. 4.
      "A functional GTP-binding motif is necessary for antiviral activity of Mx proteins."
      Pitossi F. , Blank A. , Schroeder A. , Schwarz A. , Huessi P. , Schwemmle M. , Pavlovic J. , Staeheli P.
      J. Virol.67:6726-6732(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF SER-47 AND LYS-49
    5. 5.
      "The Mx1 gene protects mice against the pandemic 1918 and highly lethal human H5N1 influenza viruses."
      Tumpey T.M. , Szretter K.J. , Van Hoeven N. , Katz J.M. , Kochs G. , Haller O. , Garcia-Sastre A. , Staeheli P.
      J. Virol.81:10818-10821(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN RESISTANCE TO INFLUENZA VIRUS
    6. 6.
      "The Mx GTPase family of interferon-induced antiviral proteins."
      Haller O. , Stertz S. , Kochs G.
      Microbes Infect.9:1636-1643(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW;INDUCTION
    7. 7.
      "Interferon-induced antiviral protein MxA interacts with the cellular RNA helicases UAP56 and URH49."
      Wisskirchen C. , Ludersdorfer T.H. , Mueller D.A. , Moritz E. , Pavlovic J.
      J. Biol. Chem.286:34743-34751(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;INTERACTION WITH DDX39A AND DDX39B
    8. 8.
      "Efficient influenza B virus propagation due to deficient interferon-induced antiviral activity in MDCK cells."
      Frensing T. , Seitz C. , Heynisch B. , Patzina C. , Kochs G. , Reichl U.
      Vaccine29:7125-7129(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    9. 9.
      "Molecular signatures associated with Mx1-mediated resistance to highly pathogenic influenza virus infection: mechanisms of survival."
      Cilloniz C. , Pantin-Jackwood M.J. , Ni C. , Carter V.S. , Korth M.J. , Swayne D.E. , Tumpey T.M. , Katze M.G.
      J. Virol.86:2437-2446(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: RESISTANCE TO INFLUENZA VIRUS
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